Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (2011, 2012, 2015)

Modular genes
Gene Product description NDA class
accD4 propionyl-CoA carboxylase subunit beta AccD 1.36
adhD alcohol dehydrogenase D 7
ald L-alanine dehydrogenase 29
alkA bifunctional regulatory protein/DNA repair enzyme AlkA 12
atpA ATP synthase subunit alpha 1.32
atsA arylsulfatase AtsA 1.11
bioA adenosylmethionine-8-amino-7-oxononanoate aminotransferase 1.2
bioB biotin synthetase 1.2
birA bifunctional biotin operon repressor/biotin--[acetyl-CoA-carboxylase] synthetase 1.2
carA carbamoyl-phosphate synthase small subunit 1.41
carB carbamoyl-phosphate synthase large subunit 1.41
ccdA cytochrome C-type biogenesis protein CcdA 1.34
ccsA cytochrome C-type biogenesis protein CcsA 1.34
cdsA phosphatidate cytidylyltransferase 1.41
celA2a -- 1.33
clpB chaperone protein ClpB 1.27
cmr HTH-type transcriptional regulator Cmr 1.28
csd cysteine desulfurase 1.1
cspA cold shock protein A 11
ctpJ cation transporter ATPase J 22
ctpV copper transporter ATPase V 1.26
cyp138 cytochrome P450 Cyp138 1.32
cyp143 cytochrome P450 Cyp143 1.3
cysA1 -- 1.22
cysD sulfate adenylyltransferase subunit 2 26
cysG multifunctional uroporphyrin-III C-methyltransferase/precorrin-2 oxidase/ferrochelatase 1.3
cysO sulfur carrier protein CysO 1.32
ddn deazaflavin-dependent nitroreductase 1.34
desA1 acyl-ACP desaturase DesA 1.19
desA3 stearoyl-CoA 9-desaturase 15
dnaA chromosomal replication initiator protein DnaA 14
dnaJ1 chaperone protein DnaJ 1.27
dnaK chaperone protein DnaK 1.27
dnaN DNA polymerase III subunit beta 14
drrA daunorubicin ABC transporter ATP-binding protein DrrA 1.4
drrB daunorubicin ABC transporter permease DrrB 1.4
drrC daunorubicin ABC transporter permease DrrC 1.4
dsbF lipoprotein DsbF 1.34
dus tRNA-dihydrouridine synthase 1.31
echA11 enoyl-CoA hydratase EchA11 3
echA4 enoyl-CoA hydratase EchA4 12
embA arabinosyltransferase A 13
embB arabinosyltransferase B 13
embC arabinosyltransferase C 13
embR transcriptional regulator EmbR 13
espB ESX-1 secretion-associated protein EspB 1.42
espD ESX-1 secretion-associated protein EspD 1.36
etfB electron transfer flavoprotein subunit beta 8
fabG short-chain type dehydrogenase/reductase 8
fadA2 acetyl-CoA acetyltransferase FadA 8
fadA5 acetyl-CoA acetyltransferase FadA 1.14
fadB5 oxidoreductase FadB 10
fadD13 long chain-fatty-acid--CoA ligase FadD13 7
fadD26 fatty-acid--CoA ligase FadD26 1.4
fadD35 fatty-acid--CoA ligase FadD35 1.24
fadE23 acyl-CoA dehydrogenase FadE23 1.36
fadE24 acyl-CoA dehydrogenase FadE24 8
fadE26 acyl-CoA dehydrogenase FadE26 1.8
fadE28 acyl-CoA dehydrogenase FadE28 1.30
fadE29 acyl-CoA dehydrogenase FadE29 1.30
fadE34 acyl-CoA dehydrogenase FadE34 15
fadE5 acyl-CoA dehydrogenase FadE5 22
fadE8 acyl-CoA dehydrogenase FadE8 12
fadE9 acyl-CoA dehydrogenase FadE9 17
frr ribosome recycling factor 1.41
ftsZ cell division protein FtsZ 3
furA ferric uptake regulation protein FurA 10
gap glyceraldehyde 3-phosphate dehydrogenase 1.3
gca GDP-mannose 4,6-dehydratase 3
glcB malate synthase 11
glgP glycogen phosphorylase 6
glpQ2 glycerophosphoryl diester phosphodiesterase GlpQ 1.36
grcC2 polyprenyl-diphosphate synthase GrcC 1.38
grpE protein GrpE 1.27
guaA GMP synthase 14
guaB inosine-5'-monophosphate dehydrogenase 14
gyrA DNA gyrase subunit A 11
gyrB DNA gyrase subunit B 11
hbhA heparin binding hemagglutinin HbhA 1.33
hemL glutamate-1-semialdehyde 2,1-aminomutase 1.34
higA3 transcriptional regulator 31
higB3 hypothetical protein 31
hmp 3-ketosteroid-9-alpha-hydroxylase reductase subunit 1.14
hrcA heat-inducible transcription repressor HrcA 1.38
hsaA flavin-dependent monooxygenase oxygenase subunit HsaA 1.14
hsp heat shock protein 1.27
hspR heat shock protein transcriptional repressor HspR 1.27
hspX alpha-crystallin 1.43
iniB isoniazid inducible protein IniB 4
ispD 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1.12
kasA 3-oxoacyl-ACP synthase 1 1.17
katG catalase-peroxidase 10
kdpA potassium-transporting ATPase subunit A 16
kdpB potassium-transporting ATPase subunit B 16
kdpC potassium-transporting ATPase subunit C 16
kdpE transcriptional regulator KdpE 16
kmtR HTH-type transcriptional regulator KmtR 5
lat L-lysine-epsilon aminotransferase 1.1
leuB 3-isopropylmalate dehydrogenase 1.3
lipR acetyl-hydrolase LipR 7
lipX lipase LipX 1.11
lppL lipoprotein LppL 2
lppW alanine-rich lipoprotein LppW 2
lpqQ lipoprotein LpqQ 23
lpqT lipoprotein LpqT 1.36
lpqY trehalose ABC transporter substrate-binding lipoprotein LpqY 6
lprD lipoprotein LprD 24
lprO lipoprotein LprO 1.36
malQ 4-alpha-glucanotransferase 6
mazE6 antitoxin MazE6 1.9
mdh malate dehydrogenase 1.28
mmpL6 transmembrane transport protein MmpL6 1.32
mmsA methylmalonate-semialdehyde dehydrogenase 17
mmsB 3-hydroxyisobutyrate dehydrogenase 17
moaC1 cyclic pyranopterin monophosphate synthase accessory protein 1.8
moaR1 transcriptional regulator MoaR 1.18
moeW molybdopterin biosynthesis protein MoeW 1.16
moeZ adenylyltransferase/sulfurtransferase 1.32
moxR2 methanol dehydrogenase transcriptional regulator MoxR 1.4
moxR3 methanol dehydrogenase transcriptional regulator MoxR 1.40
mpt53 soluble secreted antigen Mpt53 1.22
mshB 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase 1.11
mycP4 membrane-anchored mycosin 1.10
mymA FAD-containing monooxygenase MymA 7
nadA quinolinate synthetase A 1.17
nadB L-aspartate oxidase 1.17
nadC nicotinate-nucleotide pyrophosphatase 1.17
nadR transcriptional regulator NadR 1.17
narL nitrate/nitrite response transcriptional regulator NarL 1.34
nirD nitrite reductase small subunit NirD 1.3
nmtR HTH-type transcriptional regulator NmtR 22
nrdF1 ribonucleoside-diphosphate reductase subunit beta NrdF1 1.29
ogt methylated-DNA--protein-cysteine methyltransferase 12
panB 3-methyl-2-oxobutanoate hydroxymethyltransferase 4
papA4 polyketide synthase associated protein PapA 1.22
papA5 phthiocerol/phthiodiolone dimycocerosyl transferase 1.4
PE31 PE family protein PE31 3
PE34 PE family protein PE34 1.1
PE35 PE family protein PE35 1.42
pepN aminopeptidase PepN 1.22
PE_PGRS38 PE-PGRS family protein PE_PGRS38 5
PE_PGRS6 PE-PGRS family protein PE_PGRS6 1.28
PE_PGRS61 PE-PGRS family-related protein PE_PGRS61 4
pfkB 6-phosphofructokinase PfkB 1.43
pflA pyruvate formate lyase activating protein PflA 8
pgk phosphoglycerate kinase 1.3
pgsA3 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 1.27
pimA alpha-(1-2)-phosphatidylinositol mannosyltransferase 1.1
pimE polyprenol-phosphate-mannose-dependent alpha-(1-2)-phosphatidylinositol pentamannoside mannosyltransferase 1.8
pknH serine/threonine-protein kinase PknH 13
pknK serine/threonine-protein kinase PknK 6
pks10 chalcone synthase 1.22
pks13 polyketide synthase 1.36
pks3 polyketide beta-ketoacyl synthase 1.38
pncB2 nicotinic acid phosphoribosyltransferase PncB2 1.17
ppdK pyruvate, phosphate dikinase PpdK 1.3
ppe17 PPE family protein PPE17 1.36
PPE43 PPE family protein PPE43 1.10
ppe44 PPE family protein PPE44 2
PPE56 PPE family protein PPE56 4
ppe57 PPE family protein PPE57 1.9
ppe59 PPE family protein PPE59 1.24
ppe61 PPE family protein PPE61 1.14
ppe66 PPE family protein PPE66 3
ppsA phthiocerol synthesis polyketide synthase type I PpsA 1.4
ppsB phthiocerol synthesis polyketide synthase type I PpsB 1.4
ppsC phthiocerol synthesis polyketide synthase type I PpsC 1.4
ppsD phthiocerol synthesis polyketide synthase type I PpsD 1.4
ppsE phthiocerol synthesis polyketide synthase type I PpsE 1.4
proX glycine betaine/carnitine/choline/L-proline ABC transporter substrate-binding lipoprotein ProX 18
proZ glycine betaine/carnitine/choline/L-proline ABC transporter permease ProZ 1.24
pyk pyruvate kinase 1.3
pyrB aspartate carbamoyltransferase 1.41
pyrC dihydroorotase 1.41
pyrF orotidine 5'-phosphate decarboxylase 1.41
pyrH uridylate kinase 1.41
pyrR bifunctional pyrimidine operon regulatory protein/uracil phosphoribosyltransferase 1.41
recF DNA replication/repair protein RecF 14
relA bifunctional (p)ppGpp synthase/hydrolase RelA 28
rmlB dTDP-glucose 4,6-dehydratase 20
rocA pyrroline-5-carboxylate dehydrogenase RocA 21
rpmJ 50S ribosomal protein L36 19
rpsB 30S ribosomal protein S2 3
rpsD 30S ribosomal protein S4 4
rpsM 30S ribosomal protein S13 19
rslA anti-sigma-L factor RslA 1.22
rsmA anti-sigma-M factor RsmA 2
Rv0007 membrane protein 11
Rv0010c membrane protein 1.19
Rv0042c transcriptional regulator 3
Rv0043c HTH-type transcriptional regulator 18
Rv0067c transcriptional regulator 1.13
Rv0068 oxidoreductase 1.13
Rv0076c membrane protein 9
Rv0077c oxidoreductase 25
Rv0078 transcriptional regulator 25
Rv0094c hypothetical protein 4
Rv0158 transcriptional regulator 1.35
Rv0178 Mce associated membrane protein 1.36
Rv0188 transmembrane protein 1.10
Rv0191 MFS-type transporter 9
Rv0194 multidrug ABC transporter ATPase/permease 9
Rv0195 two component transcriptional regulator 9
Rv0232 transcriptional regulator 1.5
Rv0238 transcriptional regulator 8
Rv0250c hypothetical protein 1.27
Rv0260c transcriptional regulator 1.1
Rv0275c transcriptional regulator 5
Rv0276 hypothetical protein 5
Rv0307c hypothetical protein 3
Rv0308 integral membrane protein 3
Rv0330c hypothetical protein 1.20
Rv0331 dehydrogenase/reductase 1.20
Rv0338c iron-sulfur-binding reductase 1.10
Rv0339c transcriptional regulator 4
Rv0340 hypothetical protein 4
Rv0385 monooxygenase 1.27
Rv0439c dehydrogenase/reductase 1.38
Rv0472c HTH-type transcriptional regulator 1.19
Rv0474 HTH-type transcriptional regulator 1.33
Rv0520 -- 5
Rv0525 hypothetical protein 1.34
Rv0526 thioredoxin 1.34
Rv0528 transmembrane protein 1.34
Rv0574c hypothetical protein 1.17
Rv0674 hypothetical protein 12
Rv0681 transcriptional regulator 1.14
Rv0792c transcriptional regulator 17
Rv0825c hypothetical protein 5
Rv0826 hypothetical protein 5
Rv0830 S-adenosylmethionine-dependent methyltransferase 3
Rv0885 hypothetical protein 1.44
Rv0891c hypothetical protein 19
Rv0894 transcriptional regulator 1.37
Rv0947c -- 1.9
Rv0966c hypothetical protein 1.1
Rv0968 hypothetical protein 1.26
Rv0970 integral membrane protein 1.26
Rv0990c hypothetical protein 1.38
Rv0992c hypothetical protein 1.38
Rv1019 transcriptional regulator 15
Rv1024 membrane protein 1.16
Rv1126c hypothetical protein 1.3
Rv1139c hypothetical protein 1.22
Rv1158c hypothetical protein 1.8
Rv1167c transcriptional regulator 1.11
Rv1176c hypothetical protein 1.2
Rv1186c hypothetical protein 21
Rv1234 transmembrane protein 6
Rv1265 hypothetical protein 1.28
Rv1287 HTH-type transcriptional regulator 26
Rv1290A hypothetical protein 1.24
Rv1332 transcriptional regulator 1.9
Rv1342c hypothetical protein 24
Rv1352 hypothetical protein 9
Rv1374c hypothetical protein 1.28
Rv1382 hypothetical protein 1.41
Rv1460 transcriptional regulator 1.1
Rv1461 hypothetical protein 1.1
Rv1462 hypothetical protein 1.1
Rv1465 nitrogen fixation related protein 1.1
Rv1466 hypothetical protein 1.1
Rv1489A hypothetical protein 20
Rv1501 hypothetical protein 1.8
Rv1503c -- 1.35
Rv1556 HTH-type transcriptional regulator 1.32
Rv1584c phage protein 2
Rv1590 hypothetical protein 1.8
Rv1669 hypothetical protein 1.28
Rv1670 hypothetical protein 1.28
Rv1674c transcriptional regulator 1.10
Rv1773c transcriptional regulator 1.6
Rv1774 oxidoreductase 1.6
Rv1828 HTH-type transcriptional regulator 3
Rv1895 zinc-binding alcohol dehydrogenase 1.16
Rv1907c hypothetical protein 10
Rv1910c hypothetical protein 10
Rv1911c lipoprotein LppC 10
Rv1954A -- 1.1
Rv1954c hypothetical protein 1.1
Rv2016 hypothetical protein 1.30
Rv2017 transcriptional regulator 1.30
Rv2023A -- 1.1
Rv2028c universal stress protein 1.43
Rv2030c hypothetical protein 1.43
Rv2117 hypothetical protein 6
Rv2137c hypothetical protein 2
Rv2148c hypothetical protein 2
Rv2175c DNA-binding protein 1.39
Rv2204c hypothetical protein 1.22
Rv2205c hypothetical protein 1.22
Rv2323c hypothetical protein 1.10
Rv2331 hypothetical protein 2
Rv2331A hypothetical protein 2
Rv2466c hypothetical protein 1.22
Rv2506 TetR family transcriptional regulator 1.24
Rv2621c transcriptional regulator 1.1
Rv2622 methyltransferase 1.1
Rv2640c ArsR family transcriptional regulator 1.23
Rv2669 GCN5-like N-acetyltransferase 1.15
Rv2700 alanine-rich protein 9
Rv2742c arginine-rich protein 3
Rv2743c transmembrane alanine-rich protein 1.27
Rv2744c alanine-rich protein 1.27
Rv2779c Lrp/AsnC family transcriptional regulator 29
Rv2827c hypothetical protein 20
Rv2877c integral membrane protein 1.22
Rv2879c -- 1.41
Rv2880c -- 1.41
Rv2884 transcriptional regulator 1.32
Rv2912c TetR family HTH-type transcriptional regulator 27
Rv2913c D-amino acid aminohydrolase 27
Rv2971 oxidoreductase 1.28
Rv3030 S-adenosylmethionine-dependent methyltransferase 8
Rv3049c monooxygenase 1.44
Rv3050c AsnC family transcriptional regulator 1.44
Rv3058c TetR family transcriptional regulator 23
Rv3066 DeoR family transcriptional regulator 1.8
Rv3087 diacyglycerol O-acyltransferase 7
Rv3094c hypothetical protein 30
Rv3095 HTH-type transcriptional regulator 30
Rv3131 NAD(P)H nitroreductase 1.19
Rv3142c hypothetical protein 1.8
Rv3143 response regulator 1.8
Rv3161c dioxygenase 1.24
Rv3167c TetR family transcriptional regulator 1.16
Rv322E -- 28
Rv3230c stearoyl-CoA 9-desaturase electron transfer partner 15
Rv3269 hypothetical protein 21
Rv3277 transmembrane protein 1.8
Rv3334 MerR family transcriptional regulator 1.26
Rv3405c HTH-type transcriptional regulator 1.7
Rv3406 dioxygenase 1.7
Rv3463 hypothetical protein 1.12
Rv3492c Mce associated protein 1.36
Rv3520c coenzyme F420-dependent oxidoreductase 1.8
Rv3521 hypothetical protein 1.8
Rv3531c hypothetical protein 1.14
Rv3587c membrane protein 2
Rv3647c hypothetical protein 4
Rv3660c hypothetical protein 5
Rv3661 hypothetical protein 5
Rv3678c hypothetical protein 1.43
Rv3693 membrane protein 4
Rv3706c proline-rich protein 4
Rv3728 membrane protein 1.24
Rv3747 hypothetical protein 1.1
Rv3760 membrane protein 18
Rv3778c aminotransferase 1.42
Rv3779 transmembrane protein 1.42
Rv3832c hypothetical protein 1.25
Rv3833 AraC family transcriptional regulator 1.25
Rv3848 transmembrane protein 1.29
Rv3863 alanine-rich protein 9
Rv3888c membrane protein 1.44
sadH oxidoreductase SadH 7
scoA succinyl-CoA:3-ketoacid-CoA transferase subunit A 1.24
secA2 protein translocase subunit SecA 1.8
sepF cell division protein SepF 2
sigJ ECF RNA polymerase sigma factor SigJ 1.21
sigL ECF RNA polymerase sigma factor SigL 1.22
sirR transcriptional repressor SirR 1.29
ssb single-strand DNA-binding protein 1.12
sufC ABC transporter ATP-binding protein 1.1
sugA sugar ABC transporter permease SugA 6
sugB sugar ABC transporter permease SugB 6
sugC sugar ABC transporter ATP-binding protein SugC 6
tgs1 diacyglycerol O-acyltransferase 1.19
tgs4 diacyglycerol O-acyltransferase 7
tpiA triosephosphate isomerase 1.3
trxB1 thioredoxin 1.22
trxC thioredoxin TrxC 1.32
uppP undecaprenyl-diphosphatase 2
vapB15 antitoxin VapB15 1.36
vapB33 antitoxin VapB33 1.28
vapC14 ribonuclease VapC14 1.1
vapC15 ribonuclease VapC15 1.36
vapC33 ribonuclease VapC33 1.28
virS HTH-type transcriptional regulator VirS 7
whiB2 transcriptional regulator WhiB2 2
whiB6 transcriptional regulator WhiB6 1.42